http://www.spzlab.co...side/Causes.pdf
Va, jei sužinotume, kad fragmentacija virš 50, tai net ICSi nėra išeitis..
ICSI (microinsemination)
When the DFI value is above 25, the ICSI treatment will be the most efficient type of fertility treatment. Here, the likelihood of a positive outcome is approximately 50% greater as compared with the IVF treatment.
In approximately 2-3% of involuntary childless couples, the DFI value will even be above 50. In such cases, it can be difficult to get a child, even through ICSI treatment. Prior to initiating ICSI treatment, it is therefore very important to look into any possible causes in the man that could explain the high DFI value.
Explanation: The ICSI treatment is very gentle towards sperm cells with the poorly packaged genetic material. ICSI treatment helps the sperm cell all the way into the egg. Contrary to IUI treatment, it will be spared the long journey through uterus and fallopian tubes. And, compared with IVF treatment, it will not have to penetrate the thick egg membrane, either. For DFI values above 25, ICSI treatment will therefore be the best suited type of fertility treatment. For DFI values above 50, however, the genetic material is extremely fragile. It will not take much for it to fragment. Even with respect to ICSI treatment, a reduced success rate should be expected. It is therefore important that you examine the causes, prior to initiating any fertility treatment. Maybe you should consider a treatment combining ICSI with the harvesting of sperm cells directly from the scrotum. Most recent research indicates that such sperm cells will be more robust and less susceptible to DNA fragmentation (Greco et al. 2005, Wertmann et al. 2010).
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